[HTML][HTML] Smad3 prevents β-catenin degradation and facilitates β-catenin nuclear translocation in chondrocytes
Our previous study demonstrated that transforming growth factor (TGF)-β activates β-catenin
signaling through Smad3 interaction with β-catenin in chondrocytes. In the present studies,
we further investigated the detailed molecular mechanism of the cross-talk between TGF-
β/Smad3 and Wnt/β-catenin signaling pathways. We found that C-terminal Smad3 interacted
with both the N-terminal region and the middle region of β-catenin protein in a TGF-β-
dependent manner. Both Smad3 and Smad4 were required for the interaction with β-catenin …
signaling through Smad3 interaction with β-catenin in chondrocytes. In the present studies,
we further investigated the detailed molecular mechanism of the cross-talk between TGF-
β/Smad3 and Wnt/β-catenin signaling pathways. We found that C-terminal Smad3 interacted
with both the N-terminal region and the middle region of β-catenin protein in a TGF-β-
dependent manner. Both Smad3 and Smad4 were required for the interaction with β-catenin …