Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation
JF Tanti, J Jager - Current opinion in pharmacology, 2009 - Elsevier
Insulin receptor substrates (IRS) serine phosphorylation is a time-controlled physiological
feedback mechanism in insulin signaling that is hijacked by metabolic and inflammatory
stresses to promote insulin resistance. Kinases, including IKKβ, JNK, ERK, mTOR, and S6K,
activated by the inducers of insulin resistance induce uncontrolled IRS serine
phosphorylation. Studies with genetically modified mice reveal that these kinases integrate
signals from metabolic and inflammatory stresses in adipose tissue, liver, and hypothalamus …
feedback mechanism in insulin signaling that is hijacked by metabolic and inflammatory
stresses to promote insulin resistance. Kinases, including IKKβ, JNK, ERK, mTOR, and S6K,
activated by the inducers of insulin resistance induce uncontrolled IRS serine
phosphorylation. Studies with genetically modified mice reveal that these kinases integrate
signals from metabolic and inflammatory stresses in adipose tissue, liver, and hypothalamus …