Seven-transmembrane receptors

KL Pierce, RT Premont, RJ Lefkowitz - Nature reviews Molecular cell …, 2002 - nature.com
Nature reviews Molecular cell biology, 2002nature.com
Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most
versatile family of membrane receptors, are also the most common target of therapeutic
drugs. Recent findings indicate that the classical models of G-protein coupling and activation
of second-messenger-generating enzymes do not fully explain their remarkably diverse
biological actions.
Abstract
Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings indicate that the classical models of G-protein coupling and activation of second-messenger-generating enzymes do not fully explain their remarkably diverse biological actions.
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