The SLCO (former SLC21) superfamily of transporters
B Hagenbuch, B Stieger - Molecular aspects of medicine, 2013 - Elsevier
The members of the organic anion transporting polypeptide superfamily (OATPs) are
classified within the SLCO solute carrier family. All functionally well characterized members
are predicted to have 12 transmembrane domains and are sodium-independent transport
systems that mediate the transport of a broad range of endo-as well as xenobiotics.
Substrates are mainly amphipathic organic anions with a molecular weight of more than
300Da, but some of the known transported substrates are also neutral or even positively …
classified within the SLCO solute carrier family. All functionally well characterized members
are predicted to have 12 transmembrane domains and are sodium-independent transport
systems that mediate the transport of a broad range of endo-as well as xenobiotics.
Substrates are mainly amphipathic organic anions with a molecular weight of more than
300Da, but some of the known transported substrates are also neutral or even positively …