The cyclin dependent kinase inhibitor (R)-roscovitine mediates selective suppression of alloreactive human T cells but preserves pathogen-specific and leukemia …
A Nellore, B Liu, N Patsoukis, VA Boussiotis, L Li - Clinical Immunology, 2014 - Elsevier
Graft versus host disease (GvHD), mediated by donor T cells, remains the primary cause of
non-relapse mortality after allogeneic hematopoietic stem cell transplantation and novel
therapeutic approaches are required. Cdk2 is a critical node of signal integration and
programming of T cell responses towards immunity versus anergy but is dispensable for
hematopoiesis and thymocyte development. We examined the effects of pharmacologic
Cdk2 inhibition on alloreactive human T cells. Inhibition of Cdk2 blocked expansion of …
non-relapse mortality after allogeneic hematopoietic stem cell transplantation and novel
therapeutic approaches are required. Cdk2 is a critical node of signal integration and
programming of T cell responses towards immunity versus anergy but is dispensable for
hematopoiesis and thymocyte development. We examined the effects of pharmacologic
Cdk2 inhibition on alloreactive human T cells. Inhibition of Cdk2 blocked expansion of …