[HTML][HTML] Hedgehog signalling in the embryonic mouse thymus
A Barbarulo, CI Lau, K Mengrelis, S Ross… - Journal of …, 2016 - mdpi.com
A Barbarulo, CI Lau, K Mengrelis, S Ross, A Solanki, JI Saldaña, T Crompton
Journal of developmental biology, 2016•mdpi.comT cells develop in the thymus, which provides an essential environment for T cell fate
specification, and for the differentiation of multipotent progenitor cells into major
histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the
role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC)
development, and thymocyte–TEC cross-talk in the embryonic mouse thymus during the last
week of gestation.
specification, and for the differentiation of multipotent progenitor cells into major
histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the
role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC)
development, and thymocyte–TEC cross-talk in the embryonic mouse thymus during the last
week of gestation.
T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte–TEC cross-talk in the embryonic mouse thymus during the last week of gestation.
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