Chelators for investigating zinc metalloneurochemistry
RJ Radford, SJ Lippard - Current opinion in chemical biology, 2013 - Elsevier
RJ Radford, SJ Lippard
Current opinion in chemical biology, 2013•ElsevierThe physiology and pathology of mobile zinc signaling has become an important topic in
metalloneurochemistry. To study the action of mobile zinc effectively, specialized tools are
required that probe the temporal and positional changes of zinc ions within live tissue and
cells. In the present article we describe the design and implementation of selective zinc
chelators as antagonists to interrogate the function of mobile zinc, with an emphasis on the
pools of vesicular zinc in the terminals of hippocampal mossy fiber buttons.
metalloneurochemistry. To study the action of mobile zinc effectively, specialized tools are
required that probe the temporal and positional changes of zinc ions within live tissue and
cells. In the present article we describe the design and implementation of selective zinc
chelators as antagonists to interrogate the function of mobile zinc, with an emphasis on the
pools of vesicular zinc in the terminals of hippocampal mossy fiber buttons.
The physiology and pathology of mobile zinc signaling has become an important topic in metalloneurochemistry. To study the action of mobile zinc effectively, specialized tools are required that probe the temporal and positional changes of zinc ions within live tissue and cells. In the present article we describe the design and implementation of selective zinc chelators as antagonists to interrogate the function of mobile zinc, with an emphasis on the pools of vesicular zinc in the terminals of hippocampal mossy fiber buttons.
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