[HTML][HTML] Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the …
D Ziemnicka-Kotula, J Xu, H Gu, A Potempska… - Journal of Biological …, 1998 - ASBMB
Spectrin is a widely expressed protein with specific isoforms found in erythroid and
nonerythroid cells. Spectrin contains an Src homology 3 (SH3) domain of unknown function.
A cDNA encoding a candidate spectrin SH3 domain-binding protein was identified by
interaction screening of a human brain expression library using the human erythroid spectrin
(αI) SH3 domain as a bait. Five isoforms of the αI SH3 domain-binding protein mRNA were
identified in human brain. Mapping of SH3 binding regions revealed the presence of two αI …
nonerythroid cells. Spectrin contains an Src homology 3 (SH3) domain of unknown function.
A cDNA encoding a candidate spectrin SH3 domain-binding protein was identified by
interaction screening of a human brain expression library using the human erythroid spectrin
(αI) SH3 domain as a bait. Five isoforms of the αI SH3 domain-binding protein mRNA were
identified in human brain. Mapping of SH3 binding regions revealed the presence of two αI …