Pancreatic β-cells in the islets of Langerhans play a crucial role in regulating glucose
homeostasis in the circulation. Loss of β-cell mass or function due to environmental, genetic
and immunological factors leads to the manifestation of diabetes mellitus. The mechanisms
regulating the dynamics of pancreatic β-cell mass during normal development and diabetes
progression are complex. To fully unravel such complexity, experimental and clinical
approaches need to be combined with mathematical and computational models. In the …