Widespread amyloid deposition in transplanted human pancreatic islets
GT Westermark, P Westermark, C Berne… - New England Journal …, 2008 - Mass Medical Soc
GT Westermark, P Westermark, C Berne, O Korsgren
New England Journal of Medicine, 2008•Mass Medical SocTo the Editor: We report on a patient with type 1 diabetes mellitus, diagnosed at 16 years of
age, in whom widespread amyloid deposits developed many years later in transplanted
human islets. The islets were administered through three intraportal infusions: two infusions
were administered 4 months apart when the patient was 50 years of age, and one infusion
was administered when he was 54 years of age. Before the first implantation, the treatment
of the patient, who had a functioning renal transplant, was switched to the Edmonton …
age, in whom widespread amyloid deposits developed many years later in transplanted
human islets. The islets were administered through three intraportal infusions: two infusions
were administered 4 months apart when the patient was 50 years of age, and one infusion
was administered when he was 54 years of age. Before the first implantation, the treatment
of the patient, who had a functioning renal transplant, was switched to the Edmonton …
To the Editor: We report on a patient with type 1 diabetes mellitus, diagnosed at 16 years of age, in whom widespread amyloid deposits developed many years later in transplanted human islets. The islets were administered through three intraportal infusions: two infusions were administered 4 months apart when the patient was 50 years of age, and one infusion was administered when he was 54 years of age.
Before the first implantation, the treatment of the patient, who had a functioning renal transplant, was switched to the Edmonton immunosuppression protocol (i.e., daclizumab, tacrolimus, and sirolimus). After the second islet transplantation, the . . .
The New England Journal Of Medicine