[HTML][HTML] Suppressor of cytokine signaling (SOCS) 1 regulates interleukin-4 (IL-4)-activated insulin receptor substrate (IRS)-2 tyrosine phosphorylation in monocytes …
SM McCormick, N Gowda, JX Fang… - Journal of Biological …, 2016 - ASBMB
Allergic asthma is a chronic lung disease initiated and driven by Th2 cytokines IL-4/-13. In
macrophages, IL-4/-13 bind IL-4 receptors, which signal through insulin receptor substrate
(IRS)-2, inducing M2 macrophage differentiation. M2 macrophages correlate with disease
severity and poor lung function, although the mechanisms that regulate M2 polarization are
not understood. Following IL-4 exposure, suppressor of cytokine signaling (SOCS) 1 is
highly induced in human monocytes. We found that siRNA knockdown of SOCS1 prolonged …
macrophages, IL-4/-13 bind IL-4 receptors, which signal through insulin receptor substrate
(IRS)-2, inducing M2 macrophage differentiation. M2 macrophages correlate with disease
severity and poor lung function, although the mechanisms that regulate M2 polarization are
not understood. Following IL-4 exposure, suppressor of cytokine signaling (SOCS) 1 is
highly induced in human monocytes. We found that siRNA knockdown of SOCS1 prolonged …