Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells
HA Anderson, CA Maylock, JA Williams… - Nature …, 2003 - nature.com
HA Anderson, CA Maylock, JA Williams, CP Paweletz, H Shu, E Shacter
Nature immunology, 2003•nature.comRapid phagocytosis of apoptotic cells is thought to limit the development of inflammation and
autoimmune disease. Serum enhances macrophage phagocytosis of apoptotic cells. Here
we identified protein S as the factor responsible for serum-stimulated phagocytosis of
apoptotic cells. Protein S is best known for its anti-thrombotic activity, serving as a cofactor
for protein C. Purified protein S was equivalent to serum in its ability to stimulate
macrophage phagocytosis of apoptotic lymphoma cells, and immunodepletion of protein S …
autoimmune disease. Serum enhances macrophage phagocytosis of apoptotic cells. Here
we identified protein S as the factor responsible for serum-stimulated phagocytosis of
apoptotic cells. Protein S is best known for its anti-thrombotic activity, serving as a cofactor
for protein C. Purified protein S was equivalent to serum in its ability to stimulate
macrophage phagocytosis of apoptotic lymphoma cells, and immunodepletion of protein S …
Abstract
Rapid phagocytosis of apoptotic cells is thought to limit the development of inflammation and autoimmune disease. Serum enhances macrophage phagocytosis of apoptotic cells. Here we identified protein S as the factor responsible for serum-stimulated phagocytosis of apoptotic cells. Protein S is best known for its anti-thrombotic activity, serving as a cofactor for protein C. Purified protein S was equivalent to serum in its ability to stimulate macrophage phagocytosis of apoptotic lymphoma cells, and immunodepletion of protein S eliminated the prophagocytic activity of serum. Protein S acted by binding to phosphatidylserine expressed on the apoptotic cell surface. Protein S is thus a multifunctional protein that can facilitate clearance of early apoptotic cells in addition to regulating blood coagulation.
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