[HTML][HTML] The role of γ-carboxylation in the anti-apoptotic function of gas6
I Hasanbasic, I Rajotte, M Blostein - Journal of Thrombosis and …, 2005 - Elsevier
Gas6 is a novel member of the vitamin K-dependent family of γ-carboxylated proteins and is
a ligand for the receptor tyrosine kinase Axl. Gas6–Axl interactions have been shown to
mediate cell survival in vascular endothelium. Although the receptor-binding portion of gas6
lies in the C-terminus, the significance of the N-terminal γ-carboxylated residues (Gla
domain) is not clear. To address this question, this study examines the role of the Gla
domain in phospholipid binding as well as in the promotion of cell survival, especially in …
a ligand for the receptor tyrosine kinase Axl. Gas6–Axl interactions have been shown to
mediate cell survival in vascular endothelium. Although the receptor-binding portion of gas6
lies in the C-terminus, the significance of the N-terminal γ-carboxylated residues (Gla
domain) is not clear. To address this question, this study examines the role of the Gla
domain in phospholipid binding as well as in the promotion of cell survival, especially in …