[HTML][HTML] Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)
Y Atagi, CC Liu, MM Painter, XF Chen… - Journal of Biological …, 2015 - ASBMB
Several heterozygous missense mutations in the triggering receptor expressed on myeloid
cells 2 (TREM2) have recently been linked to risk for a number of neurological disorders
including Alzheimer disease (AD), Parkinson disease, and frontotemporal dementia. These
discoveries have re-ignited interest in the role of neuroinflammation in the pathogenesis of
neurodegenerative diseases. TREM2 is highly expressed in microglia, the resident immune
cells of the central nervous system. Along with its adaptor protein, DAP12, TREM2 regulates …
cells 2 (TREM2) have recently been linked to risk for a number of neurological disorders
including Alzheimer disease (AD), Parkinson disease, and frontotemporal dementia. These
discoveries have re-ignited interest in the role of neuroinflammation in the pathogenesis of
neurodegenerative diseases. TREM2 is highly expressed in microglia, the resident immune
cells of the central nervous system. Along with its adaptor protein, DAP12, TREM2 regulates …