Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE

JJ Orme, Y Du, K Vanarsa, J Mayeux, L Li… - Clinical …, 2016 - Elsevier
Systemic lupus erythematosus (SLE) is characterized by antibody-mediated chronic
inflammation in the kidney, lung, skin, and other organs to cause inflammation and damage.
Several inflammatory pathways are dysregulated in SLE, and understanding these
pathways may improve diagnosis and treatment. In one such pathway, Axl tyrosine kinase
receptor responds to Gas6 ligand to block inflammation in leukocytes. A soluble form of the
Axl receptor ectodomain (sAxl) is elevated in serum from patients with SLE and lupus-prone …