[HTML][HTML] Direct interactions between HIF-1α and Mdm2 modulate p53 function
The p53 tumor suppressor is maintained at low levels in normal cells by Mdm2-mediated
degradation and strongly stabilized in response to various types of stress including hypoxia.
Although hypoxia-inducible factor 1α (HIF-1α) has been implicated to be involved in p53
stabilization, the precise mechanism by which HIF-1α regulates p53-mediated function
remains unknown. Here, we found that HIF-1α directly binds Mdm2 both in vitro andin vivo;
in contrast, p53 fails to directly interact with HIF-1α in vitro. Interestingly, Mdm2 expression …
degradation and strongly stabilized in response to various types of stress including hypoxia.
Although hypoxia-inducible factor 1α (HIF-1α) has been implicated to be involved in p53
stabilization, the precise mechanism by which HIF-1α regulates p53-mediated function
remains unknown. Here, we found that HIF-1α directly binds Mdm2 both in vitro andin vivo;
in contrast, p53 fails to directly interact with HIF-1α in vitro. Interestingly, Mdm2 expression …