Persistent pulmonary hypertension in high-risk congenital diaphragmatic hernia patients: incidence and vasodilator therapy

AP Bos, D Tibboel, VCM Koot, FWJ Hazebroek… - Journal of pediatric …, 1993 - Elsevier
Survival of congenital diaphragmatic hernia patients depends on the gravity of pulmonary
hypoplasia and persistent pulmonary hypertension (PPH). Many vasoactive drugs have
been used in the treatment of PPH, but often they also lower peripheral resistance, leading
to a significant drop in arterial blood pressure. The incidence of PPH in 52 high-risk
diaphragmatic hernia patients and the results of treatment with tolazoline and prostacyclin
were evaluated in a study lasting 52 months and involving 52 patients. High-risk patients …