Evaluation of variability in inhaled nitric oxide use and pulmonary hypertension in patients with congenital diaphragmatic hernia

LR Putnam, K Tsao, F Morini, PA Lally, CC Miller… - JAMA …, 2016 - jamanetwork.com
Importance Inhaled nitric oxide (iNO) is an expensive, commonly used therapy among
patients with congenital diaphragmatic hernia (CDH); however, data to support its ongoing
use in this patient population are lacking. Objective To describe the spectrum of iNO use
among patients with CDH and its association with pulmonary hypertension (pHTN) and
mortality. Design, Setting, and Participants A review was conducted of prospectively
collected patient data in the Congenital Diaphragmatic Hernia Study Group registry between …