Myelination and oligodendrocyte functions in psychiatric diseases

KA Nave, H Ehrenreich - JAMA psychiatry, 2014 - jamanetwork.com
The evolution of the human brain is marked not only by a major expansion of the neocortex
but also by an enormous increase of the subcortical white matter. White matter tracts
comprise the axonal output of some 1010 cortical projection neurons, which constitute a
giant cellular network, recently referred to as the connectome. About half the human brain
comprises myelinated axonal tracts that connect the cortex with subcortical structures and,
most importantly, interconnect cortical areas with each other. Lesions affecting central …