Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans
SA Oppelt, EM Sennott, DR Tolan - Molecular genetics and metabolism, 2015 - Elsevier
The rise in fructose consumption, and its correlation with symptoms of metabolic syndrome
(MBS), has highlighted the need for a better understanding of fructose metabolism. To that
end, valid rodent models reflecting the same metabolism as in humans, both biochemically
and physiologically, are critical. A key to understanding any type of metabolism comes from
study of disease states that affect such metabolism. A serious defect of fructose metabolism
is the autosomal recessive condition called hereditary fructose intolerance (HFI), caused by …
(MBS), has highlighted the need for a better understanding of fructose metabolism. To that
end, valid rodent models reflecting the same metabolism as in humans, both biochemically
and physiologically, are critical. A key to understanding any type of metabolism comes from
study of disease states that affect such metabolism. A serious defect of fructose metabolism
is the autosomal recessive condition called hereditary fructose intolerance (HFI), caused by …