[HTML][HTML] Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension
S Barone, SL Fussell, AK Singh, F Lucas, J Xu… - Journal of Biological …, 2009 - ASBMB
The identity of the transporter responsible for fructose absorption in the intestine in vivo and
its potential role in fructose-induced hypertension remain speculative. Here we demonstrate
that Glut5 (Slc2a5) deletion reduced fructose absorption by∼ 75% in the jejunum and
decreased the concentration of serum fructose by∼ 90% relative to wild-type mice on
increased dietary fructose. When fed a control (60% starch) diet, Glut5-/-mice had normal
blood pressure and displayed normal weight gain. However, whereas Glut5+/+ mice …
its potential role in fructose-induced hypertension remain speculative. Here we demonstrate
that Glut5 (Slc2a5) deletion reduced fructose absorption by∼ 75% in the jejunum and
decreased the concentration of serum fructose by∼ 90% relative to wild-type mice on
increased dietary fructose. When fed a control (60% starch) diet, Glut5-/-mice had normal
blood pressure and displayed normal weight gain. However, whereas Glut5+/+ mice …