Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage
V Lindström, G Gustafsson, LH Sanders… - Molecular and Cellular …, 2017 - Elsevier
The presence of Lewy bodies, mainly consisting of aggregated α-synuclein, is a pathological
hallmark of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The α-
synuclein inclusions are predominantly found in neurons, but also appear frequently in
astrocytes. However, the pathological significance of α-synuclein inclusions in astrocytes
and the capacity of glial cells to clear toxic α-synuclein species remain unknown. In the
present study we investigated uptake, degradation and toxic effects of oligomeric α …
hallmark of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The α-
synuclein inclusions are predominantly found in neurons, but also appear frequently in
astrocytes. However, the pathological significance of α-synuclein inclusions in astrocytes
and the capacity of glial cells to clear toxic α-synuclein species remain unknown. In the
present study we investigated uptake, degradation and toxic effects of oligomeric α …