Trisomy 12 is associated with an abbreviated redistribution lymphocytosis during treatment with the BTK inhibitor ibrutinib in patients with chronic lymphocytic …
PA Thompson, A Ferrajoli, S O'Brien… - British journal of …, 2015 - search.ebscohost.com
British journal of haematology, 2015•search.ebscohost.com
The article discusses a study investigating association between trisomy 12 (T12)
chromosome and redistribution lymphocytosis during the treatment with Ibrutinib in chronic
lymphocytic leukemia (CLL) patients. It states that B-cell receptor (BCR) signaling is
essential for proliferation and survival of CLL cells. It mentions that integrin-mediated
signaling could promote retention of T12 cells within the tissues.
chromosome and redistribution lymphocytosis during the treatment with Ibrutinib in chronic
lymphocytic leukemia (CLL) patients. It states that B-cell receptor (BCR) signaling is
essential for proliferation and survival of CLL cells. It mentions that integrin-mediated
signaling could promote retention of T12 cells within the tissues.
Abstract
The article discusses a study investigating association between trisomy 12 (T12) chromosome and redistribution lymphocytosis during the treatment with Ibrutinib in chronic lymphocytic leukemia (CLL) patients. It states that B-cell receptor (BCR) signaling is essential for proliferation and survival of CLL cells. It mentions that integrin-mediated signaling could promote retention of T12 cells within the tissues.
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