The cancer biomarker problem

CL Sawyers - Nature, 2008 - nature.com
Nature, 2008nature.com
Genomic technologies offer the promise of a comprehensive understanding of cancer.
These technologies are being used to characterize tumours at the molecular level, and
several clinical successes have shown that such information can guide the design of drugs
targeted to a relevant molecule. One of the main barriers to further progress is identifying the
biological indicators, or biomarkers, of cancer that predict who will benefit from a particular
targeted therapy.
Abstract
Genomic technologies offer the promise of a comprehensive understanding of cancer. These technologies are being used to characterize tumours at the molecular level, and several clinical successes have shown that such information can guide the design of drugs targeted to a relevant molecule. One of the main barriers to further progress is identifying the biological indicators, or biomarkers, of cancer that predict who will benefit from a particular targeted therapy.
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