[HTML][HTML] Activation of Wnt11 by transforming growth factor-β drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells
P Zhang, Y Cai, A Soofi, GR Dressler - Journal of Biological Chemistry, 2012 - ASBMB
Transforming growth factor β1 (TGF-β) promotes renal interstitial fibrosis in vivo and the
expression of mesenchymal genes in vitro; however, most of its direct targets in epithelial
cells are still elusive. In a screen for genes directly activated by TGF-β, we found that
components of the Wnt signaling pathway, especially Wnt11, were targets of activation by
TGF-β and Smad3 in primary renal epithelial cells. In gain and loss of function experiments,
Wnt11 mediated the actions of TGF-β through enhanced activation of mesenchymal marker …
expression of mesenchymal genes in vitro; however, most of its direct targets in epithelial
cells are still elusive. In a screen for genes directly activated by TGF-β, we found that
components of the Wnt signaling pathway, especially Wnt11, were targets of activation by
TGF-β and Smad3 in primary renal epithelial cells. In gain and loss of function experiments,
Wnt11 mediated the actions of TGF-β through enhanced activation of mesenchymal marker …