The histone methyltransferase enzyme enhancer of zeste homolog 2 protects against podocyte oxidative stress and renal injury in diabetes
FS Siddiqi, S Majumder, K Thai, M Abdalla… - Journal of the …, 2016 - journals.lww.com
Epigenetic regulation of oxidative stress is emerging as a critical mediator of diabetic
nephropathy. In diabetes, oxidative damage occurs when there is an imbalance between
reactive oxygen species generation and enzymatic antioxidant repair. Here, we investigated
the function of the histone methyltransferase enzyme enhancer of zeste homolog 2 (EZH2)
in attenuating oxidative injury in podocytes, focusing on its regulation of the endogenous
antioxidant inhibitor thioredoxin interacting protein (TxnIP). Pharmacologic or genetic …
nephropathy. In diabetes, oxidative damage occurs when there is an imbalance between
reactive oxygen species generation and enzymatic antioxidant repair. Here, we investigated
the function of the histone methyltransferase enzyme enhancer of zeste homolog 2 (EZH2)
in attenuating oxidative injury in podocytes, focusing on its regulation of the endogenous
antioxidant inhibitor thioredoxin interacting protein (TxnIP). Pharmacologic or genetic …