Regulation of the protein stability of EMT transcription factors

VM Diaz, R Vinas-Castells… - Cell adhesion & …, 2014 - Taylor & Francis
VM Diaz, R Vinas-Castells, A Garcia de Herreros
Cell adhesion & migration, 2014Taylor & Francis
The epithelial to mesenchymal transition (EMT) consists of a rapid change of cell phenotype,
characterized by the loss of epithelial characteristics and the acquisition of a more invasive
phenotype. Transcription factors regulating EMT (Snail, Twist and Zeb) are extremely labile
proteins, rapidly degraded by the proteasome system. In this review we analyze the current
mechanisms controlling degradation of EMT transcription factors, focusing on the role of new
E3 ubiquitin-ligases involved in EMT. We also summarize the regulation of the stability of …
The epithelial to mesenchymal transition (EMT) consists of a rapid change of cell phenotype, characterized by the loss of epithelial characteristics and the acquisition of a more invasive phenotype. Transcription factors regulating EMT (Snail, Twist and Zeb) are extremely labile proteins, rapidly degraded by the proteasome system. In this review we analyze the current mechanisms controlling degradation of EMT transcription factors, focusing on the role of new E3 ubiquitin-ligases involved in EMT. We also summarize the regulation of the stability of these EMT transcription factors, specially observed in different stress conditions, such as hypoxia, chemotherapeutic drugs, oxidative stress or γ-irradiation.
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