[HTML][HTML] Transcriptional regulation and its misregulation in disease
TI Lee, RA Young - Cell, 2013 - cell.com
TI Lee, RA Young
Cell, 2013•cell.comThe gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators.
Misregulation of these gene expression programs can cause a broad range of diseases.
Here, we review recent advances in our understanding of transcriptional regulation and
discuss how these have provided new insights into transcriptional misregulation in disease.
are controlled by thousands of transcription factors, cofactors, and chromatin regulators.
Misregulation of these gene expression programs can cause a broad range of diseases.
Here, we review recent advances in our understanding of transcriptional regulation and
discuss how these have provided new insights into transcriptional misregulation in disease.
The gene expression programs that establish and maintain specific cell states in humans are controlled by thousands of transcription factors, cofactors, and chromatin regulators. Misregulation of these gene expression programs can cause a broad range of diseases. Here, we review recent advances in our understanding of transcriptional regulation and discuss how these have provided new insights into transcriptional misregulation in disease.
cell.com