Sibling rivalry in the E2F family
JM Trimarchi, JA Lees - Nature reviews Molecular cell biology, 2002 - nature.com
Nature reviews Molecular cell biology, 2002•nature.com
The E2F transcription factor family determines whether or not a cell will divide by controlling
the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct
subgroups that act in direct opposition to one another to promote either cellular proliferation
or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this'
push-me–pull-you'regulation, and what are its biological consequences?
the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct
subgroups that act in direct opposition to one another to promote either cellular proliferation
or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this'
push-me–pull-you'regulation, and what are its biological consequences?
Abstract
The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this 'push-me–pull-you' regulation, and what are its biological consequences?
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