[PDF][PDF] SPOP mutations or ERG rearrangements result in enhanced levels of ERG to promote cell invasion in prostate cancer
S Duan, M Pagano - Molecular cell, 2015 - cell.com
S Duan, M Pagano
Molecular cell, 2015•cell.comIn this issue, An et al.(2015) and Gan et al.(2015) reveal that the CRL3 SPOP ubiquitin
ligase mediates the degradation of the transcription factor ERG and that translocations of
ERG or mutations in SPOP prevent CRL3 SPOP-dependent degradation of ERG in prostate
cancer cells.
ligase mediates the degradation of the transcription factor ERG and that translocations of
ERG or mutations in SPOP prevent CRL3 SPOP-dependent degradation of ERG in prostate
cancer cells.
In this issue, An et al. (2015) and Gan et al. (2015) reveal that the CRL3SPOP ubiquitin ligase mediates the degradation of the transcription factor ERG and that translocations of ERG or mutations in SPOP prevent CRL3SPOP-dependent degradation of ERG in prostate cancer cells.
cell.com