P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic Drosophila melanogaster
WA Zehring, DA Wheeler, P Reddy, RJ Konopka… - Cell, 1984 - cell.com
WA Zehring, DA Wheeler, P Reddy, RJ Konopka, CP Kyriacou, M Rosbash, JC Hall
Cell, 1984•cell.comMutations at the period (Per) locus of Drosophila melanogaster disrupt several biological
rhythms. Molecular cloning of DNA sequences encompassing the per+ locus has allowed
germ-line transformation experiments to be carried out. Certain subsegments of the per
region, transduced into the genome of arrhythmic per “flies, restore rhythmic@ in circadian
locomotor behavior and the male's courtship song.
rhythms. Molecular cloning of DNA sequences encompassing the per+ locus has allowed
germ-line transformation experiments to be carried out. Certain subsegments of the per
region, transduced into the genome of arrhythmic per “flies, restore rhythmic@ in circadian
locomotor behavior and the male's courtship song.
Summary
Mutations at the period (Per) locus of Drosophila melanogaster disrupt several biological rhythms. Molecular cloning of DNA sequences encompassing the per+ locus has allowed germ-line transformation experiments to be carried out. Certain subsegments of the per region, transduced into the genome of arrhythmic per “flies, restore rhythmic@ in circadian locomotor behavior and the male’s courtship song.
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