Wounds that heal and wounds that don't− The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis
NL Millar, C O'Donnell, IB McInnes, E Brint - Seminars in Cell & …, 2017 - Elsevier
NL Millar, C O'Donnell, IB McInnes, E Brint
Seminars in Cell & Developmental Biology, 2017•ElsevierIL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the
nucleus of cells where it plays a role in gene regulation. Given the right combination of
signals and cellular damage, stored IL-33 is released from the cell where it can interact with
its receptor ST2, triggering danger-associated responses and act as a cellular “alarmin”.
Whilst IL-33/ST2 signalling has been shown to induce potent pro-inflammatory responses
that can be detrimental in certain disease states, a dichotomous, protective role of IL-33 in …
nucleus of cells where it plays a role in gene regulation. Given the right combination of
signals and cellular damage, stored IL-33 is released from the cell where it can interact with
its receptor ST2, triggering danger-associated responses and act as a cellular “alarmin”.
Whilst IL-33/ST2 signalling has been shown to induce potent pro-inflammatory responses
that can be detrimental in certain disease states, a dichotomous, protective role of IL-33 in …
Abstract
IL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the nucleus of cells where it plays a role in gene regulation. Given the right combination of signals and cellular damage, stored IL-33 is released from the cell where it can interact with its receptor ST2, triggering danger-associated responses and act as a cellular “alarmin”. Whilst IL-33/ST2 signalling has been shown to induce potent pro-inflammatory responses that can be detrimental in certain disease states, a dichotomous, protective role of IL-33 in promoting wound healing has also emerged in multiple tissues types. This review will explore the current literature concerning this homeostatic role of IL-33/ST2 in tissue repair and also review its role in uncontrolled wound responses as seen in both fibrosis and tumorigenesis.
Elsevier