[HTML][HTML] Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-β receptor signaling pathways contributes …
H Chung, R Ramachandran, MD Hollenberg… - Journal of Biological …, 2013 - ASBMB
Chronic kidney diseases cause significant morbidity and mortality in the population. During
renal injury, kidney-localized proteinases can signal by cleaving and activating proteinase-
activated receptor-2 (PAR2), a G-protein-coupled receptor involved in inflammation and
fibrosis that is highly expressed in renal tubular cells. Following unilateral ureteric
obstruction, PAR2-deficient mice displayed reduced renal tubular injury, fibrosis, collagen
synthesis, connective tissue growth factor (CTGF), and α-smooth muscle actin gene …
renal injury, kidney-localized proteinases can signal by cleaving and activating proteinase-
activated receptor-2 (PAR2), a G-protein-coupled receptor involved in inflammation and
fibrosis that is highly expressed in renal tubular cells. Following unilateral ureteric
obstruction, PAR2-deficient mice displayed reduced renal tubular injury, fibrosis, collagen
synthesis, connective tissue growth factor (CTGF), and α-smooth muscle actin gene …