[HTML][HTML] Synthesis and catabolism of γ-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2
RC Lyon, SM Johnston, DG Watson, G McGarvie… - Journal of Biological …, 2007 - ASBMB
γ-Hydroxybutyrate (GHB) is an endogenous metabolite synthesized in the brain. There is
strong evidence to suggest that GHB has an important role as a neurotransmitter or
neuromodulator. The human aldo-keto reductase AKR7A2 has been proposed previously to
catalyze the NADPH-dependent reduction of succinic semialdehyde (SSA) to GHB in human
brain. In this study we have used RNA interference to evaluate the role of AKR7A2 in GHB
biosynthesis in human neuroblastoma SH-SY5Y cells. Quantitative reverse transcription …
strong evidence to suggest that GHB has an important role as a neurotransmitter or
neuromodulator. The human aldo-keto reductase AKR7A2 has been proposed previously to
catalyze the NADPH-dependent reduction of succinic semialdehyde (SSA) to GHB in human
brain. In this study we have used RNA interference to evaluate the role of AKR7A2 in GHB
biosynthesis in human neuroblastoma SH-SY5Y cells. Quantitative reverse transcription …