Conditional mutation of Pkd2 causes cystogenesis and upregulates β-catenin
Abstract Loss of polycystin-2 (PC2) in mice (Pkd2−/−) results in total body edema, focal
hemorrhage, structural cardiac defects, abnormal left-right axis, hepatorenal and pancreatic
cysts, and embryonic lethality. The molecular mechanisms by which loss of PC2 leads to
these phenotypes remain unknown. We generated a model to allow targeted Pkd2
inactivation using the Cre-loxP system. Global inactivation of Pkd2 produced a phenotype
identical to Pkd2−/− mice with undetectable PC2 protein and perinatal lethality. Using …
hemorrhage, structural cardiac defects, abnormal left-right axis, hepatorenal and pancreatic
cysts, and embryonic lethality. The molecular mechanisms by which loss of PC2 leads to
these phenotypes remain unknown. We generated a model to allow targeted Pkd2
inactivation using the Cre-loxP system. Global inactivation of Pkd2 produced a phenotype
identical to Pkd2−/− mice with undetectable PC2 protein and perinatal lethality. Using …