[HTML][HTML] Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
Cell dysfunction and death induced by lipid accumulation in nonadipose tissues, or
lipotoxicity, may contribute to the pathogenesis of obesity and type 2 diabetes. However, the
mechanisms leading to lipotoxic cell death are poorly understood. We recently reported that,
in Chinese hamster ovary (CHO) cells and in H9c2 cardiomyoblasts, lipid overload induced
by incubation with 500 μM palmitate leads to intracellular accumulation of reactive oxygen
species, which subsequently induce endoplasmic reticulum (ER) stress and cell death …
lipotoxicity, may contribute to the pathogenesis of obesity and type 2 diabetes. However, the
mechanisms leading to lipotoxic cell death are poorly understood. We recently reported that,
in Chinese hamster ovary (CHO) cells and in H9c2 cardiomyoblasts, lipid overload induced
by incubation with 500 μM palmitate leads to intracellular accumulation of reactive oxygen
species, which subsequently induce endoplasmic reticulum (ER) stress and cell death …