[HTML][HTML] HLA antibody detection with solid phase assays: great expectations or expectations too great?
HM Gebel, RA Bray - American Journal of Transplantation, 2014 - Elsevier
Alloantibodies directed against HLA antigens, are a barrier to long-term solid organ allograft
survival. The clinical impact of preformed, donor-directed HLA alloantibodies range from
acceptable risk to unequivocal contraindication for organ transplantation. HLA antibodies
are key factors that limit patient access to donor organs. Serological methods were once the
only approach to identify HLA antigens and antibodies. Limitations in these technologies led
to the development of solid phase approaches. In the early 1990s, the development of the …
survival. The clinical impact of preformed, donor-directed HLA alloantibodies range from
acceptable risk to unequivocal contraindication for organ transplantation. HLA antibodies
are key factors that limit patient access to donor organs. Serological methods were once the
only approach to identify HLA antigens and antibodies. Limitations in these technologies led
to the development of solid phase approaches. In the early 1990s, the development of the …