[HTML][HTML] A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody
T Hirohashi, CM Chase, P Della Pelle… - American Journal of …, 2012 - Elsevier
Chronic allograft vasculopathy (CAV) in murine heart allografts can be elicited by adoptive
transfer of donor specific antibody (DSA) to class I MHC antigens and is independent of
complement. Here we address the mechanism by which DSA causes CAV. B6. RAG1−/− or
B6. RAG1−/− C3−/−(H-2 b) mice received B10. BR (H-2 k) heart allografts and repeated
doses of IgG2a, IgG1 or F (ab') 2 fragments of IgG2a DSA (anti-H-2 k). Intact DSA regularly
elicited markedly stenotic CAV in recipients over 28 days. In contrast, depletion of NK cells …
transfer of donor specific antibody (DSA) to class I MHC antigens and is independent of
complement. Here we address the mechanism by which DSA causes CAV. B6. RAG1−/− or
B6. RAG1−/− C3−/−(H-2 b) mice received B10. BR (H-2 k) heart allografts and repeated
doses of IgG2a, IgG1 or F (ab') 2 fragments of IgG2a DSA (anti-H-2 k). Intact DSA regularly
elicited markedly stenotic CAV in recipients over 28 days. In contrast, depletion of NK cells …