IgG donor-specific anti-human HLA antibody subclasses and kidney allograft antibody-mediated injury
C Lefaucheur, D Viglietti, C Bentlejewski… - Journal of the …, 2016 - journals.lww.com
Antibodies may have different pathogenicities according to IgG subclass. We investigated
the association between IgG subclasses of circulating anti-human HLA antibodies and
antibody-mediated kidney allograft injury. Among 635 consecutive kidney transplantations
performed between 2008 and 2010, we enrolled 125 patients with donor-specific anti-
human HLA antibodies (DSA) detected in the first year post-transplant. We assessed DSA
characteristics, including specificity, HLA class specificity, mean fluorescence intensity (MFI) …
the association between IgG subclasses of circulating anti-human HLA antibodies and
antibody-mediated kidney allograft injury. Among 635 consecutive kidney transplantations
performed between 2008 and 2010, we enrolled 125 patients with donor-specific anti-
human HLA antibodies (DSA) detected in the first year post-transplant. We assessed DSA
characteristics, including specificity, HLA class specificity, mean fluorescence intensity (MFI) …