[HTML][HTML] Cancer cells compress intratumour vessels
TP Padera, BR Stoll, JB Tooredman, D Capen… - Nature, 2004 - nature.com
The delivery of therapeutic drugs to solid tumours may be impaired by structural and
functional abnormalities in blood and lymphatic vessels. Here we provide evidence that
proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing
this compressive mechanical force and opening vessels, cytotoxic cancer treatments have
the potential to increase blood perfusion, thereby improving drug delivery.
functional abnormalities in blood and lymphatic vessels. Here we provide evidence that
proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing
this compressive mechanical force and opening vessels, cytotoxic cancer treatments have
the potential to increase blood perfusion, thereby improving drug delivery.
Abstract
The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, cytotoxic cancer treatments have the potential to increase blood perfusion, thereby improving drug delivery.
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