A portal vein injection model to study liver metastasis of breast cancer
ET Goddard, J Fischer, P Schedin - JoVE (Journal of Visualized …, 2016 - jove.com
Breast cancer is the leading cause of cancer-related mortality in women worldwide. Liver
metastasis is involved in upwards of 30% of cases with breast cancer metastasis, and results
in poor outcomes with median survival rates of only 4.8-15 months. Current rodent models of
breast cancer metastasis, including primary tumor cell xenograft and spontaneous tumor
models, rarely metastasize to the liver. Intracardiac and intrasplenic injection models do
result in liver metastases, however these models can be confounded by concomitant …
metastasis is involved in upwards of 30% of cases with breast cancer metastasis, and results
in poor outcomes with median survival rates of only 4.8-15 months. Current rodent models of
breast cancer metastasis, including primary tumor cell xenograft and spontaneous tumor
models, rarely metastasize to the liver. Intracardiac and intrasplenic injection models do
result in liver metastases, however these models can be confounded by concomitant …