Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury
A Douglass, K Wallace, R Parr, J Park, E Durward… - Journal of …, 2008 - Elsevier
BACKGROUND/AIMS: Myofibroblast apoptosis promotes the resolution of liver fibrosis.
However, retaining macrophages may enhance reversal. The effects of specifically
stimulating myofibroblast apoptosis in vivo were assessed. METHODS: A single chain
antibody (C1-3) to an extracellular domain of a myofibroblast membrane protein was
injected as a fluorescent-or gliotoxin conjugate into mice with liver fibrosis. RESULTS: C1-3
specifically targeted α-smooth muscle actin positive liver myofibroblasts within scar regions …
However, retaining macrophages may enhance reversal. The effects of specifically
stimulating myofibroblast apoptosis in vivo were assessed. METHODS: A single chain
antibody (C1-3) to an extracellular domain of a myofibroblast membrane protein was
injected as a fluorescent-or gliotoxin conjugate into mice with liver fibrosis. RESULTS: C1-3
specifically targeted α-smooth muscle actin positive liver myofibroblasts within scar regions …