Lifespan of liver cells: autoradiographic study using tritiated thymidine in normal, cirrhotic, and partially hepatectomized rats
RA MacDONALD - Archives of internal medicine, 1961 - jamanetwork.com
Little information is available concerning the lifespan of liver cells in the normal and
diseased liver. This is a study of the length of time that newly formed hepatic nuclei
containing tritium (H 3)-labeled deoxyribonucleic acid (DNA) remain in the liver in normal
rats and mice, and in rats with fatty, cirrhotic, and partially hepatectomized liver. The method
was as follows. It has been observed that thymidine is a specific precursor of DNA, 1 which
is considered to be relatively stable until a cell prepares for division, at which time the cell …
diseased liver. This is a study of the length of time that newly formed hepatic nuclei
containing tritium (H 3)-labeled deoxyribonucleic acid (DNA) remain in the liver in normal
rats and mice, and in rats with fatty, cirrhotic, and partially hepatectomized liver. The method
was as follows. It has been observed that thymidine is a specific precursor of DNA, 1 which
is considered to be relatively stable until a cell prepares for division, at which time the cell …