2-acetylaminofluorene dose-dependent differentiation of rat oval cells into hepatocytes: confocal and electron microscopic studies
S Paku, P Nagy, L Kopper, SS Thorgeirsson - Hepatology, 2004 - journals.lww.com
Abstract The 2-acetylaminofluorene (AAF)/partial hepatectomy (PH) model is one of the most
extensively studied experimental systems for oval cell proliferation and differentiation. We
have previously described the oval cells as forming ductular structures surrounded by
basement membrane, representing extensions of the canals of Hering. Herein we analyze
the differentiation of oval cells into hepatocytes after varying degrees of liver damage
induced by AAF. At a low dose of AAF, most oval cells synchronously differentiate into small …
extensively studied experimental systems for oval cell proliferation and differentiation. We
have previously described the oval cells as forming ductular structures surrounded by
basement membrane, representing extensions of the canals of Hering. Herein we analyze
the differentiation of oval cells into hepatocytes after varying degrees of liver damage
induced by AAF. At a low dose of AAF, most oval cells synchronously differentiate into small …