Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis
L Hammerich, JM Bangen, O Govaere… - Hepatology, 2014 - journals.lww.com
Chronic liver injury promotes hepatic inflammation, representing a prerequisite for organ
fibrosis. We hypothesized a contribution of chemokine receptor CCR6 and its ligand,
CCL20, which may regulate migration of T-helper (Th) 17, regulatory, and gamma-delta (γδ)
T cells. CCR6 and CCL20 expression was intrahepatically up-regulated in patients with
chronic liver diseases (n= 50), compared to control liver (n= 5). Immunohistochemistry
revealed the periportal accumulation of CCR6+ mononuclear cells and CCL20 induction by …
fibrosis. We hypothesized a contribution of chemokine receptor CCR6 and its ligand,
CCL20, which may regulate migration of T-helper (Th) 17, regulatory, and gamma-delta (γδ)
T cells. CCR6 and CCL20 expression was intrahepatically up-regulated in patients with
chronic liver diseases (n= 50), compared to control liver (n= 5). Immunohistochemistry
revealed the periportal accumulation of CCR6+ mononuclear cells and CCL20 induction by …