BackgroundlAims: Chronic cholestasis stimulates a fibroductular reaction which may
progress to secondary biliary fibrosis and cirrhosis. Since platelet-de-rived growth factor has
been indicated as a major fibrogenic factor in chronic liver disease, we analyzed its
expression and that of its receptor β subunit in a rat model of chronic cholestasis. Methods:
Liver tissue samples collected at 7, 10, 21, and 28 days after induction of cholestasis
obtained by bile duct ligation, were analyzed by immunohistochemistry, in situ hybridization …