Familial vesicoureteral reflux: testing replication of linkage in seven new multigenerational kindreds
S Sanna-Cherchi, A Reese, T Hensle… - Journal of the …, 2005 - journals.lww.com
Abstract Vesicoureteral reflux (VUR)(OMIM% 193000), a common cause of childhood renal
failure, is strongly influenced by hereditary factors. Familial VUR most closely conforms to
autosomal-dominant inheritance, but because of variable penetrance and expressivity, large
multigenerational pedigrees tractable to linkage analysis have been difficult to ascertain. A
single genome-wide study of familial VUR has demonstrated linkage to chromosome 1p13,
with 78% locus heterogeneity. Previous studies in humans have also suggested loci on …
failure, is strongly influenced by hereditary factors. Familial VUR most closely conforms to
autosomal-dominant inheritance, but because of variable penetrance and expressivity, large
multigenerational pedigrees tractable to linkage analysis have been difficult to ascertain. A
single genome-wide study of familial VUR has demonstrated linkage to chromosome 1p13,
with 78% locus heterogeneity. Previous studies in humans have also suggested loci on …