Circulating barrier disruptive agonists bind specific cell membrane receptors and trigger
signal transduction pathways leading to the activation of cell contractility and endothelial cell
(EC) permeability. Although all cells in tissues including vascular EC are surrounded by
compliant extracellular matrix, the impact of matrix stiffness on agonist-induced signaling,
cytoskeletal remodeling and EC barrier regulation is not well understood. This study
examined agonist-induced cytoskeletal and signaling changes associated with EC barrier …