The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial–stellate cell deactivation induced by statins
G Marrone, L Russo, E Rosado, D Hide… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: Statins improve hepatic endothelial function and liver fibrosis in
experimental models of cirrhosis, thus they have been proposed as therapeutic options to
ameliorate portal hypertension syndrome. The transcription factor Kruppel-like factor 2
(KLF2) may be induced by statins in liver sinusoidal endothelial cells (SEC), orchestrating
an efficient vasoprotective response. The present study aimed at characterizing whether
KLF2 mediates statins-derived hepatic protection. METHODS: Expression of KLF2 and its …
experimental models of cirrhosis, thus they have been proposed as therapeutic options to
ameliorate portal hypertension syndrome. The transcription factor Kruppel-like factor 2
(KLF2) may be induced by statins in liver sinusoidal endothelial cells (SEC), orchestrating
an efficient vasoprotective response. The present study aimed at characterizing whether
KLF2 mediates statins-derived hepatic protection. METHODS: Expression of KLF2 and its …