Background & Aims Activation of hepatic stellate cells (HSCs) represents a key process in
liver injury and, in the absence of intervention, leads to irreversible cirrhosis contributing
significantly to the mortality of patients with liver disease. A missing link in the current
understanding of HSC activation is the involvement of the epigenetic machinery. We
investigated the role of the myocardin related transcription factor A (MRTF-A) in HSC
activation. Methods Liver fibrosis was induced in wild type (WT) and MRTF-A deficient (KO) …